Resilient Supply Chains: PAT as a Tool for Raw Material Quality

How can PAT mitigate the risks of variable raw material quality?

One of the primary causes of batch failure is the variability in raw materials, such as excipients or growth media components. PAT tools can be used at the "Point of Entry" to create a fingerprint of incoming materials. If a lot differs significantly from the validated standard, the PAT-enabled process can automatically adjust its parameters—such as agitation speed or temperature—to compensate for the material's properties.

Is Raw Material Analytical Testing shifting toward PAT?

The traditional method of sampling a fraction of incoming containers is no longer sufficient. Implementing Raw Material Analytical Testing using handheld Raman or NIR devices allows for 100% inspection of materials at the loading dock. In 2024, this practice is drastically reducing the number of "unexpected" deviations during the production phase, saving companies millions in lost material and time.

How does PAT support the 'Just-in-Time' supply chain?

In a JIT environment, there is no time for quarantine. PAT allows for "Pre-Validated" materials to move directly into production. By sharing spectral data between the supplier and the manufacturer, the buyer can verify the quality of a lot before it even leaves the supplier's warehouse.

• Handheld NIR for rapid warehouse screening.
• Blockchain integration for material provenance and spectral data.
• AI-driven adjustment of processes based on raw material variability.

2025 Logistics Outlook

By 2025, we expect to see "Digital Passports" for pharmaceutical ingredients, where the raw material quality data is automatically fed into the manufacturer's PAT software upon arrival.

Author: Sofiya Sanjay

Designation: Healthcare Research Consultant, Market Research Future

About: At Market Research Future (MRFR), we enable organizations to unravel complex industries through Cooked Research Reports (CRR), Half-Cooked Research Reports (HCRR), Raw Research Reports (3R), Continuous-Feed Research (CFR), and Market Research & Consulting Services. Our studies across products, technologies, applications, end users, and global to country-level segments help decision-makers see more, know more, and do more.

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